Assuntos
Malondialdeído/sangue , Substâncias Reativas com Ácido Tiobarbitúrico , Adulto , Cromatografia Líquida de Alta Pressão/métodos , Humanos , Porfiria Cutânea Tardia/sangue , Porfiria Eritropoética/sangue , Padrões de Referência , Valores de Referência , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Espectrofotometria/métodosRESUMO
Despite the prevalence of cannabis use in the community, reports of adverse effects in young children are rare. Two cases of cannabis-induced coma are reported following accidental ingestion of cannabis cookies. The possibility of cannabis ingestion should be considered in cases of unexplained coma in a previously well young child if signs of conjunctival hyperaemia, pupillary dilatation and tachycardia are present and other causes such as CNS infection or trauma are unlikely. Specific screening for cannabinoids should be undertaken.
Assuntos
Cannabis , Coma/induzido quimicamente , Contaminação de Alimentos , Pré-Escolar , Serviço Hospitalar de Emergência , Humanos , Lactente , Masculino , Detecção do Abuso de SubstânciasRESUMO
In describing the clinical, biochemical, and family findings in five children with porphyria, we examine initial treatments and, where appropriate, the effectiveness of long-term therapy. We note that porphyria diagnosis, particularly in childhood, relies heavily on specialist laboratory investigations. Because disease expression in some porphyrias requires exposure to precipitating factors, it may be prevented or delayed by their avoidance.
Assuntos
Oxirredutases atuantes sobre Doadores de Grupo CH-CH , Porfirias/diagnóstico , Porfirias/terapia , Adolescente , Idoso , Ácido Aminolevulínico/urina , Criança , Pré-Escolar , Coproporfirinogênio Oxidase/sangue , Feminino , Flavoproteínas , Humanos , Hidroximetilbilano Sintase/sangue , Masculino , Proteínas Mitocondriais , Oxirredutases/sangue , Porfobilinogênio/urina , Protoporfirinogênio Oxidase , Valores de Referência , Uroporfirinogênio Descarboxilase/sangueRESUMO
A child who was grossly malnourished and who showed increased excretion of porphyrin and porphyrin precursor had normal activity of erythrocyte porphobilinogen deaminase (EC 4.3.1.8) and leukocyte protoporphyrinogen oxidase (EC 1.3.3.4). Clinical symptoms, coincident with the excretion of rose-colored urine, were consistent with the diagnosis of an acute porphyria. The disease resolved spontaneously after the withdrawal of carbamazepine and sodium valproate and the commencement of parenteral nutrition with subsequent carbohydrate loading. In addition to normal concentrations of enzyme activities, the patient is unusual in presenting before puberty and in having no family history of porphyria.
